The study was to develop a transdermal therapeutic system for ketorolac tromethamine (KT) using various polymers like ethyl cellulose (EC), hydroxy propyl methyl cellulose (HPMC) and permeation enhancers like sodium glycocholate and propylene glycol. The films were prepared by using solvent casting method and prepared films were evaluated for physicochemical properties, in-vitro drug release, ex-vivo skin permeation studies and in-vivo studies. The in-vitro release studies revealed that the release was sustained upto 24 hr and it follows zero order kinetics. Finally, the best formulation (F3) selected through in-vitro study and subjected to ex-vivo skin permeation using rat skin and in-vivo studies in rabbits. The film was also subjected to skin irritation and anti-inflammatory activity and found that there was no skin irritation and edema levels were lowered in the albino rats. As a patient friendly the transdermal film containing ketorolac tromethamine could be promising in the pasture of controlled drug delivery.
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